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Genome Architecture in Cell Fate and Disease
Gordon Research Conference

Defining Structure and Function of the Nucleus

Dates

July 2-7, 2017

Location

The Hong Kong University of Science and Technology
Hong Kong, China

Organizers

Chair:
Wange Lu

Vice Chairs:
David M. Gilbert & Yijun Ruan

Hong Kong Advisory Board:
Tony F. Chan, Kathryn Song Eng Cheah, Fanny M.C. Cheung, Arthur B. Ellis, Barry Halliwell, Nancy Ip, Jian Lu, Peter Mathieson, Alfonso Ngan, Paul Tam, Benjamin Wah, Henry Wong, Vivian Wing-Wah Yam, Kenneth Young & Albert Cheung-Hoi Yu More Information

Meeting Description

Accumulating evidence suggest that genomes are organized non-randomly into complex 3D configurations that vary according to cell type, stage of development, differentiation and disease status. The principles, which guide higher order organization, the mechanisms responsible for establishment, maintenance and alterations of higher order genome, and the functional consequences of aberrant genome and nuclear organization have become areas of intense interest. The higher-order spatial and temporal organization of genomes in the cell nucleus is rapidly emerging as a driver of biological function in differentiation, development and disease and the incorporation of information on higher order genome organization add an additional level of complexity in our understanding of genome regulation. These studies bring together several cutting edge fields including genomics, epigenetics, big data analysis, imaging and clinical cell and molecular biology. The 2017 conference on Genome Architecture in Cell Fate and Disease aims to foster a new community that is devoted to the understanding of nuclear architecture in cell fate determination, development, disease modeling, stem cell biology and regenerative medicine. Particularly emphasis will be placed on genome organization, epigenetic remodeling, chromatin folding, structural elements of the nucleus and its relevance in gene transcription. Another angle is to promote cutting edge tools that allow us to visualize the nucleus. We seek to unify and integrate chemical, biological, physiological as well as physical parameters into a coherent picture of the nucleus, especially the human one.

Contributors

Final Meeting Program

Sunday
2:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmStructure of the Nucleus
Discussion Leader: Wange Lu (University of Southern California, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:30 pmThomas Misteli (National Cancer Institute, NIH, USA)
"Deep Imaging of the Genome"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:20 pmDuanqing Pei (Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, China)
"Chromatin Remodeling During Somatic Cell Reprogramming"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm3D Nuclear Structure and Human Diseases
Discussion Leader: Thomas Misteli (National Cancer Institute, NIH, USA)
9:00 am - 9:40 amAli Shilatifard (Northwestern University, USA)
"Principles of Epigenetics and Chromatin in Development and Human Disease"
9:40 am - 9:50 amDiscussion
9:50 am - 10:30 amWoojin An (University of Southern California, USA)
"Chromatin Reorganization During Osteoclast Differentiation and Bone Metastases"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amGroup Photo / Coffee Break
11:10 am - 11:50 amJane Skok (New York University, USA)
"The Impact of Endogenous Retroviruses on Nuclear Organization in Mammalian Cells"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmBjoert Kragesteen (Max Planck Institute for Molecular Genetics, Germany)
"Chromatin Architecture at the Pitx1 Locus Translates Pan-Limb Enhancer Activity into Hindlimb Specific Transcriptional Output"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmMariana Ruiz-Velasco (European Molecular Biology Laboratory, Germany)
"CTCF-Mediated Intragenic Chromatin Looping Regulates Alternative Exon Usage"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmDynamics of 3D Nuclear Architecture
Discussion Leader: Wouter De Laat (Hubrecht Institute, The Netherlands)
7:30 pm - 8:10 pmPeter Fraser (Florida State University, USA)
"The Dynamic 3D Organization of the Genome"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 9:00 pmBing Ren (University of California, San Diego, USA)
"Analysis of Chromatin Organization After Acute Loss of CTCF in Mouse Embryonic Stem Cells"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmXiaoyuan Song (University of Science and Technology of China, China)
"The Higher Order Chromatin Reorganization During Mammalian Spermatogenesis"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmOrganization of Chromatin
Discussion Leader: Peter Fraser (Florida State University, USA)
9:00 am - 9:40 amWouter De Laat (Hubrecht Institute, The Netherlands)
"Multi-Contact 4C to Discern Cooperative and Non-Cooperative Interactions Between Genes and Regulatory Sequences"
9:40 am - 9:50 amDiscussion
9:50 am - 10:30 amYuichi Taniguchi (RIKEN, Japan)
"3D Nucleosome Organization of the Genome"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:50 amBing Zhu (Institute of Biophysics, Chinese Academy of Sciences, China)
"De Novo Establishment of DNA Methylation During Oocyte Maturation"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmMarina Lusic (University Hospital Heidelberg, Germany)
"HIV Explores Genomic Organization to Integrate and Persist"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmBo Wen (Fudan University, China)
"An Endoderm-Specific lncRNA, linc-FoxA2, Maintains 3D Genome Architecture in Liver Cells"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
2:00 pm - 4:00 pmPoster Session
4:00 pm - 6:00 pmGenome Structure, Epigenetics and Gene Transcription
Discussion Leader: Jing-Dong Han (CAS-MPG Partner Institute for Computational Biology, China)
4:00 pm - 4:40 pmRafael Casellas (National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, USA)
"Architectural Striptes Facilitate Transcription and Recombination of Ig Genes"
4:40 pm - 4:50 pmDiscussion
4:50 pm - 5:30 pmHiroshi Kimura (Tokyo Institute of Technology, Japan)
"Chromatin Modification Dynamics During Gene Activation in Living Cells"
5:30 pm - 5:40 pmDiscussion
5:40 pm - 5:55 pmJiao Sima (Florida State University, USA)
"Genetic Dissection of Functional Elements in Replication Timing Control"
5:55 pm - 6:00 pmDiscussion
6:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChromatin Structure, Stem Cells and Development
Discussion Leader: Bing Zhu (Institute of Biophysics, Chinese Academy of Sciences, China)
9:00 am - 9:40 amVictor Corces (Emory University, USA)
"Evolutionarily Conserved Principles Predict 3D Chromatin Organization"
9:40 am - 9:50 amDiscussion
9:50 am - 10:30 amWei Xie (Tsinghua University, China)
"Dynamic Chromatin Reprogramming in Early Mammalian Development"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:50 amRyan Lister (University of Western Australia, Australia)
"Conserved TET-Mediated Regulation of Enhancer Activity and Accessibility During Development"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmDanny Leung (Hong Kong University of Science and Technology, Hong Kong SAR China)
"Delineating Cis-Regulatory Function of Endogenous Retroviruses"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmBrian Chadwick (Florida State University, USA)
"A Novel Super Enhancer-Like Element Embedded Within the X-Linked IL1RAPL1 Gene Is Linked to Chromatin Compaction of the Inactive X Chromosome"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmChromatin Structure and Single Cell Epigenome
Discussion Leader: Yijun Ruan (Jackson Laboratory for Genomic Medicine, USA)
7:30 pm - 8:10 pmFuchou Tang (Peking University, China)
"Single Cell Epigenome Sequencing of Human Early Embryos"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 9:00 pmGuohong Li (National Laboratory of Biomacromolecules, Chinese Academy of Sciences, China)
"Structure and Dynamics of the 30-nm Chromatin Fiber in Gene Regulation and Epigenetic Inheritance"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmIchiro Hiratani (RIKEN Center for Developmental Biology, Japan)
"Single-Cell DNA Replication Timing Profiling and the 3D Genome Organization Dynamics"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTools and Technology to Study 4D Nucleome
Discussion Leader: Rafael Casellas (National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, USA)
9:00 am - 9:40 amQiang Wu (Shanghai Jiao Tong University, China)
"Dissection of Chromatin Looping by DNA Fragment Editing"
9:40 am - 9:50 amDiscussion
9:50 am - 10:30 amJing-Dong Han (CAS-MPG Partner Institute for Computational Biology, China)
"Cell Identity Marking and Interactions of Enhancer-Like Transposable Elements"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:50 amJian Ma (Carnegie Mellon University, USA)
"Modeling Nuclear Compartmentalization and Chromatin Interaction Using Machine Learning"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmJonas Paulsen (University of Oslo, Norway)
"Computational Modeling Reveals 4D Genome Reorganization During Stem Cell Differentiation"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmStefanie Morgan (Stanford University School of Medicine, USA)
"Manipulation of Nuclear Architecture Through CRISPR-Mediated Chromosomal Looping"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmImaging of the Nucleus
Discussion Leader: David Gilbert (Florida State University, USA)
4:00 pm - 4:40 pmKazuhiro Maeshima (National Institute of Genetics, Japan)
"Dynamic Organization of Chromatin Domains Revealed by Super-Resolution Live-Cell Imaging"
4:40 pm - 4:50 pmDiscussion
4:50 pm - 5:30 pmClodagh O'Shea (The Salk Institute for Biological Studies, USA)
"Visualizing the Higher Order Coding Structures of DNA"
5:30 pm - 5:40 pmDiscussion
5:40 pm - 5:55 pmHanhui Ma (University of Massachusetts Medical School, USA)
"CRISPR-Based Imaging Reveals Cell-Cycle-Dependent Chromosome Dynamics in Living Cells"
5:55 pm - 6:00 pmDiscussion
6:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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